Search results for "Trichomonas Infections"
showing 2 items of 2 documents
Oral trichomonosis: Description and severity of lesions in birds in Spain.
2020
Este artículo se encuentra disponible en la página web de la revista en la siguiente URL: https://www.sciencedirect.com/science/article/abs/pii/S1383576920301264 This is the pre-peer reviewed version of the following article: Martínez-Herrero, M.C., Sansano-Maestre, J., Ortega, J., González, F., López-Márquez, I., Gómez-Muñoz, M.T. et al. (2020). Oral trichomonosis: description and severity of lesions in birds in Spain. Veterinary Parasitology, vol. 283, art. 109196, which has been published in final form at https://doi.org/10.1016/j.vetpar.2020.109196. Este es el pre-print del siguiente artículo: Martínez-Herrero, M.C., Sansano-Maestre, J., Ortega, J., González, F., López-Márquez, I., Góme…
New antitrichomonal drug-like chemicals selected by bond (edge)-based TOMOCOMD-CARDD descriptors.
2008
Bond-based quadratic indices, new TOMOCOMD-CARDD molecular descriptors, and linear discriminant analysis (LDA) were used to discover novel lead trichomonacidals. The obtained LDA-based quantitative structure-activity relationships (QSAR) models, using nonstochastic and stochastic indices, were able to classify correctly 87.91% (87.50%) and 89.01% (84.38%) of the chemicals in training (test) sets, respectively. They showed large Matthews correlation coefficients of 0.75 (0.71) and 0.78 (0.65) for the training (test) sets, correspondingly. Later, both models were applied to the virtual screening of 21 chemicals to find new lead antitrichomonal agents. Predictions agreed with experimental resu…